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Cholesteryl pullulan

WebNov 1, 2006 · We previously reported that cholesteryl pullulan (CHP) deriva-tives were effective carriers drug delivery systems in targeting cancer cells. We have now synthesized folic acid-conjugated CHP... WebMar 22, 2024 · We have been developing the cholesteryl pullulan (CHP)-antigen protein nanoparticle as a cancer vaccine for esophageal cancer [ 13, 14 ]. A CHP nanoparticle that contains a tumor antigen is a new type of cancer vaccine with a novel antigen delivery system for both the MHC class I and class II pathways.

Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Eff…

WebPullulan is mainly used by the cell to resist desiccation and predation. The presence of this polysaccharide also facilitates diffusion of molecules both into and out of the cell. The … WebNov 19, 2015 · A self-assembled nanogel is constructed from light-sensitive cholesteryl pullulan (Ls-CHP) by using photo-labile ortho-nitrobenzyl (o-NB) units. The nanogel-based film is obtained by evaporation of an Ls-CHP nanogel solution. Exposure of the resulting nanogel-based film to light with a mask resulted in a pat nourish good food belfast https://jasonbaskin.com

First-in-human phase I clinical trial of the NY-ESO-1 protein cancer ...

WebJan 2, 2014 · The cholesteryl pullulan, with an average degree of substitution of 5.4 per 100 glucose units, was prepared by reacting pullulan with cholesterol succinate according to a procedure already reported (Yang et al., 2010), and the structure of CHSP is shown in Fig. 1. Download : Download full-size image; Fig. 1. The synthesis route of Bio-CHSP. WebThe CHP-HER2 vaccine, comprising truncated 146HER2 protein complexed with nanogels of cholesteryl pullulan (CHP), is a novel protein antigen vaccine that elicits 146HER2-specific CD8 (+) and CD4 (+) T-cell immune responses in … WebHere, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS). We characterized the three hydrophobically modified polymers (CHPN 1, … nourish guide

Templated Formation of Hydroxyapatite Nanoparticles from …

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Cholesteryl pullulan

Selective and Effective Cytotoxicity of Folic Acidconjugated ...

WebTo create a drug delivery system that allows the controlled release of proteins, such as growth factors, over a long-term period, cholesteryl group- and acryloyl group-bearing pullulan (CHPOA) nanogels were aggregated to form fast-degradable hydrogels (CHPOA/hydrogels) by cross-linking with thiol-bearing polyethylene glycol. WebJun 20, 2010 · A nanometre-sized hydrogel consisting of a cationic type of cholesteryl group bearing pullulan has now been used as an intranasal vaccine-delivery system.

Cholesteryl pullulan

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WebJan 1, 2014 · Intracellular delivery of exogenous proteins is a field of bioscience that has grown rapidly in recent years, driven by the potential clinical applications. We developed a protein nanocarrier composed of amphiphilic polysaccharide nanogels formed by self-assembly of ethylenediamine- and cholesteryl group-bearing pullulan (CHP-NH 2). The …

WebExpert opinion: The most advanced models of nanogel-based vaccines comprise candidates against cancer, based on cholesteryl pullulan nanogels evaluated in clinical trials with promising findings; as well as some vaccines against respiratory pathogens tested in … WebA series of biotin modified cholesteryl pullulan (Bio-CHSP) conjugates with different degrees of substitution (DS) of biotin moiety were synthesized and characterized by Fourier transform infrared (FT-IR), proton nuclear magnetic resonance ((1)H NMR) and X-ray diffraction (XRD). Bio-CHSP conjugates were amphiphilic in nature and their self ...

WebAug 3, 2024 · To harness the benefits of mucosal vaccines, various mucosal antigen delivery vehicles are under development, and a cationic cholesteryl-group-bearing pullulan nanogel (cCHP nanogel) has emerged ... WebAbstract. In this study, a novel nanoparticulate drug delivery platform with inherent targeting ability to hepatic carcinoma cells and reduction-triggered drug release …

WebJan 8, 2024 · Fujioka-Kobayashi et al. studied the combination of FGF-18 with the bone morphogenic protein (BMP)-2 and found it was sufficient at showing significant bone regeneration potential in crosslinked acrylol cholestrol modified pullulan nanogels. These factors were combined with stimulated thick trabecular bone formation . Charoenlarp et …

WebJan 2, 2014 · Synthesis of cholesteryl pullulan (CHSP) conjugates The cholesteryl pullulan, with an average degree of substitution of 5.4 per 100 glucose units, was … nourish growWebJan 24, 2024 · Cholesteryl pullulan (CHP) is a novel antigen delivery system. CHP and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen complexes (CHP-NY-ESO-1) present multiple epitope peptides to the MHC class I and II pathways. Adjuvants are essential for cancer vaccines. MIS416 is a non-toxic microparticle that activates … nourish guidelinesWebDec 6, 2012 · Self-assembled protein-loaded pH-sensitive cholesteryl pullulan-based nanogels were developed to retain the encapsulated protein at the physiological … nourish gummiesWebAn object is to provide a new cosmetic composition that can prevent or reduce skin “photoaging” caused by blue light. As a solution, a cosmetic composition is provided, which is characterized in that it contains: (a) one or more types of alkyl phosphate esters selected from alkyl phosphate esters having alkyl groups with 12 to 36 carbon atoms; (b) one or … how to sign how are you in bslWebHere, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS). We characterized the three … how to sign how in bslWebFeb 15, 2003 · The synthesized cholesteryl pullulan (CHP) was used for coating the vincristine containing liposomes. Vincristine sulphate, a potent anticancer drug, was … nourish hair salon veazie maineWebFeb 1, 2015 · Request PDF On Feb 1, 2015, Ram Sarup Singh and others published Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting Find, read and cite all the research ... how to sign how are you in asl