Cisplatin review

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August undefined, 2024

WebFeb 1, 1989 · Background: Cisplatin is a major antineo- plastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Methods: We reviewed clinical and experimental literature on... WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum …

Emerging and established therapies for chemotherapy-induced

WebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … WebMay 15, 2012 · Cisplatin is a highly effective chemotherapeutic agent but displays significant ototoxic side effects. The most prominent change seen in the cochlea after cisplatin administration consists of loss of outer hair cells. Several mechanisms are believed to mediate cisplatin-induced apoptosis: binding of cisplatin to guanine bases … eaarth making a life on a tough new planet

Cisplatin Nephrotoxicity: A Review - ScienceDirect

WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted … WebAug 1, 2007 · Cisplatin induces magnesium depletion, and magnesium deficiency itself may enhance cisplatin nephrotoxicity. Cisplatin treatment often produces extensive gastrointestinal side effects, which. Summary. In this review, we focus on the pathophysiology of toxic renal injury caused by an important chemotherapeutic agent. WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … eaas employee profile

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

Cisplatin and AKI: an ongoing battle with new perspectives

WebJun 24, 2011 · Interstrand crosslinks (ICLs) are a type of DNA damage that is induced by various chemotherapeutics, such as cisplatin. This Review discusses how these lesions are repaired through multiple ... eaa shotgun reviewWebMar 15, 2024 · Cisplatin has not yet been recognized as a potential trigger for recall reactions. Although it was part of several reported multidrug trigger combinations, all review works referred to cisplatin as not suspicious, suggesting the combination partner as the effector. We performed a focused systematic literature review aiming to re-evaluate the ... eaa shotguns for sale

"WebApr 24, 2024 · Cisplatin is a platinum-based alkylating compound that reacts with DNA to form interstrand cross-links and intrastrand bifunctional N-7 DNA adducts at d (GpG) and d (ApG) 3. Cisplatin is renally excreted and can accumulate in the renal proximal tubules, leading to nephrotoxicity. " - Cisplatin review

Cisplatin review

Cisplatin Nephrotoxicity: A Review - ScienceDirect

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

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WebJun 3, 2024 · In the present review, we investigate the role of epithelial–mesenchymal transition (EMT) in the emergence of cisplatin (CP) resistance. CP is a key member of platinum compounds with excellent anti-tumor activity against different cancers such as breast cancer, prostate cancer, bladder cancer, lung cancer, brain tumors, and so on … WebDec 12, 2024 · A recent systematic review and meta-analysis published in 2024 by Li et al. studied the effect of mannitol on cisplatin-induced nephrotoxicity. A total of 4168 patients were included and results showed that mannitol has the best effect at doses of cisplatin lower than 75 mg/m 2.

WebThis review covered the hallmarks of inflammation common and distinct between different CITs, the role of innate immune components in development of CITs, as well as current … WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head …

WebCisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cum … WebApr 5, 2024 · Abstract. Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its …

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WebJul 12, 2007 · Cisplatin is a very effective cancer drug and has had a major clinical impact, particularly for patients with testicular or ovarian cancers. But, it is notoriously toxic to the kidneys... csgo long match vs short matchWebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … eaa show timesWebCisplatin Nephrotoxicity: A Review XIN YAO, MD; KESSARIN PANICHPISAL, MD; NEIL KURTZMAN, MD; KENNETH NUGENT, MD ABSTRACT: Background: Cisplatin is a major antineo-plastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Methods: We reviewed clinical and experimental literature on cisplatin nephro- eaas infosysWebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. … csgo lounge support offerWebOct 23, 2003 · Cisplatin is a neutral inorganic, square planar complex that reacts with DNA to induce its characteristic biological effects, which culminate in either repair of the DNA damage and cell survival... cs go lounge tradesWebA systematic review was performed to evaluate clinical studies that have examined hydration and supplementation strategies to prevent cisplatin-induced nephrotoxicity. … csgolounge trading tipsWebFeb 26, 2024 · Cisplatin (Platinol) Brand Names: Platinol, Platinol-AQ, Platinol (Restricted Access) Reviewed: February 26, 2024 Cisplatin is used together with other cancer … ea as in steak