WebMay 14, 1999 · Synthetic DNA and DNA generated in bacterial systems contain unmethylated CpG motifs which stimulate the immune system. This has clear implications for DNA-based therapeutic strategies. WebJun 1, 2003 · Recent reports have identified two major classes of CpG motif-containing oligodeoxynucleotide immunostimulatory sequences (ISS): uniformly modified …
Frontiers Cooperation of Oligodeoxynucleotides and Synthetic ...
CpG motifs are considered pathogen-associated molecular patterns due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor ( PRR ) Toll-Like Receptor 9 ( TLR9 ), which is constitutively expressed only in B … See more CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers … See more Since 1893, it has been recognized that Coley's toxin, a mixture of bacterial cell lysate, has immunostimulatory properties that could reduce … See more One of the first Class A ODN, ODN 2216, was described in 2001 by Krug et al. This class of ODN was distinctly different from the previously … See more Synthetic CpG ODN differ from microbial DNA in that they have a partially or completely phosphorothioated (PS) backbone instead of the typical phosphodiester … See more Krieg et al. was the first to describe Class B ODN in 1995. Class B ODN (i.e. ODN 2007) are strong stimulators of human B cell and monocyte maturation. They also stimulate the maturation of pDC but to a lesser extent than Class A ODN and very small amounts of … See more WebSynthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B … hca fl lake monroe hospital fax
Rational engineering of a functional CpG-free ITR for AAV gene …
WebSynthetic ODNs harboring CpG motifs resembling those identified in viral/microbial DNA trigger an identical response, such that these immunomodulatory ODNs have therapeutic … The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands (or CG islands). Cytosines in CpG dinucleotides can be methylated to form 5-methylcytosines. E… WebMay 1, 1995 · Bacterial DNA and synthetic oligonucleotides that express these CpG motifs rapidly stimulate B cells, T cells, and macrophages to proliferate, secrete Abs, and/or … gold chain catalogue