Phospho s727

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August undefined, 2024

WebHere, we studied the role of STAT3 activation on tyrosine 705 (Y705) and serine 727 (S727) in glioma radioresistance. This study explored STAT3 phosphorylation on Y705 (pSTAT3-Y705) and S727 (pSTAT3-S727) in glioma cell lines and in clinical samples. Radiosensitizing effect of STAT3 activation down-modulation by Gö6976 was explored. WebProduct Name Phospho-STAT3(S727) Rabbit mAb; Host Species Rabbit ; Clonality Monoclonal ; Clone No. SY24-09 Purification ProA affinity purified; Applications WB, ICC/IF, IHC, IP; Species Reactivity Hu, RtMs; Immunogen Description Synthetic phospho-peptide corresponding to residues surrounding Ser727 of human STAT3.; Alternative Names …

Human Phospho-STAT3 (S727) Antibody AF4934: R&D Systems

WebHSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a … WebS727 phosphorylation is regulated directly by fibroblast growth factor/Erk signaling and crucial in the transition of mESCs from pluripotency to neuronal commitment. Loss of S727 phosphorylation resulted in significantly reduced neuronal differentiation potential, which could be recovered by a S727 phosphorylation mimic. ... sims 3 age up baby

Human/Mouse Phospho-Stat 1 (S727) and Total Stat 1 ELISA

WebUsing a combination of HepG2-stat3-knockdown cells reconstituted with various STAT3 mutants and protein kinase inhibitors, we showed that phospho-S727 has an intrinsic … WebApr 23, 2002 · Phosphorylation of S727 in Stat1 can be induced by a variety of stimuli such as IFN-γ, lipopolysaccharide, and UV, and p38 mitogen-activated protein (MAP) kinase has been implicated in lipopolysaccharide- or UV-induced phosphorylation of S727 in Stat1 ( … WebOct 30, 2006 · In vivo analyses of S727 of Stat1 and Stat3 using knock-in mouse models showed that S727 plays important physiological roles [13], [14]. However, the biochemical function underlying the physiological importance of the phospho-serine and conserved LPMSP motif is not completely understood. rbbc sport football

Alexa Fluor® 488 anti-STAT3 Phospho (Ser727) Antibody

Essential role of mitochondrial Stat3 in p38MAPK mediated

WebHigh expression of histone deacetylase 2 (HDAC2) is recognized as a marker of invasive breast cancer (BC). HDAC2 is not only responsible for enhancing tumor cell growth, development, and anti-apoptosis, but also plays a significant role in regulating PD-L1 on the surface of tumor cells. WebJan 11, 2012 · It has been shown that Ser727 of STAT3 is phosphorylated by various kinases, including mitogen-activated kinases (MAPK), H7-sensitive kinase, protein kinase Cδ, cyclin-dependent kinase 5 (CDK5), the mammalian target of rapamycin kinase (mTOR), nemo-like kinase (NLK), death-associated protein kinase 3 (DAPK3), and mitogen- and … sims 3 all expansion packsWebMay 4, 2024 · Serine kinases play a more nuanced role in regulating Stat3 due to direct Stat3 activation through S727 phosphorylation ( 16) by kinases such as mTOR ( 7) and others, which also have the potential for competing inhibitory effects from parallel downregulation of Stat3 tyrosine phosphorylation pathways ( 17 ). rbb demat account

"WebA phospho specific peptide corresponding to residues surrounding Serine 727 of human Stat-1 was used as an immunogen. This antibody only … " - Phospho s727

Phospho s727

Human Phospho-HSP27 (S78/S82) Antibody MAB23141: …

WebFeb 5, 2024 · TGFβ is the prototype of a large family of pluripotent cytokines with diverse effects on cellular proliferation, tumor growth, apoptosis, differentiation, fibrosis, anti-inflammation, and embryo development [1,2,3,4,5].The competence of TGFβ cytokine signaling plays an important role in determining lineage acquisition in cells of … WebWestern blot - Phospho-STAT3-S727 Rabbit pAb (AP0474) Western blot analysis of extracts of various cell lines, using Phospho-STAT3-S727 antibody (AP0474) at 1:1000 dilution.HepG2 cells and C6 cells were treated by PMA/TPA (200 nM) at 37℃ for 30 minutes after serum-starvation overnight.HepG2 cells were treated by CIP (20uL/400ul) at 37℃ for ...

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WebHuman Phospho-HSP27 (S78/S82) Antibody Summary. Species Reactivity. Human. Specificity. Detects human HSP27 when dually phosphorylated at S78/S82 in Western … WebMay 25, 2000 · The critical importance of S727 phosphorylation for the biological impact of IFN-γ is further supported by studies with mediators of inflammation (LPS, TNF-α), which cooperate with IFN-γ in the...

WebSep 30, 2008 · S727 phosphorylation enhances the transcriptional activities of Stat3, whereas mutations of S727 compromise Stat3 transactivational activity and downstream effects ( 8 ). Cooperation of both tyrosine and serine phosphorylation is necessary for full activation of Stat3 ( 4 ). WebHuman Phospho-STAT3 (S727) Antibody Summary Species Reactivity Human Specificity Detects human STAT3 when phosphorylated at S727. Source Monoclonal Mouse IgG 2B …

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WebHuman Phospho-STAT3 (S727) Antibody Summary. Detects human STAT3 when phosphorylated at S727 in Western blots. Lyophilized from a 0.2 μm filtered solution in …

WebCitations: (293) The Phospho-Stat3 (Ser727) Antibody from Cell Signaling Technology is a Rabbit Polyclonal antibody to STAT3. This antibody recognizes Human, Mouse, and Rat antigen. The Phospho-Stat3 (Ser727) Antibody has been validated for the following applications: Precipitation, ChIP, Immunoprecipitation, and Western Blot. rbb delay sportsWebFlow cytometry of Phospho-Stat1 (Ser727) using U937 cells. Samples were incubated in monoclonal Phospho-Stat1 (Ser727) antibody ( Product # MA5-37074 ). Images correspond with the following conditions: negative control (blue), stained untreated (red), treated with IFNa IL-4 and pervanadate (green). Product Details Product Specific Information rb beacon\u0027sWebProperties. Description. Rabbit Monoclonal Antibody to STAT3 (phospho S727) Background. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. rbb energie cottbus live streamWebJan 15, 2001 · S727 phosphorylation of STAT1 in interferon-γ (IFN-γ)-treated mouse fibroblasts occurred without a need for p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 or c-Jun kinases, and required both an intact SH2 domain and phosphorylation of Y701. rbbc vacation rentalsWebBoster Bio Anti-STAT3 (Phospho-S727) Antibody catalog # A00007S727-2. Tested in IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ul in Liquid form antibody. rbbf178tWebDec 21, 2012 · We used immunohistochemistry with phospho-specific antibodies to look at the presence of activated JAK2 and STAT3 in human tissues, BTSCs, and tumors from orthotopic xenografts. We found strong staining of the cell membrane for phosphorylated Y1007/1008 JAK2 and staining of the nucleus for phosphorylated Y705 and S727 STAT3 … rbbf1-hn1268WebStat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor comp rb beachhead\u0027s