http://www.satoshi-omura.info/lactacystin/index.html WebbRHEs were produced in dry atmosphere (30%–50% relative humidity) with 5% CO 2 at 37°C as previously described. 4 Clasto-lactacystin β-lactone is an irreversible and specific …

Shuhong Lei 2 Publications 190 Citations Related Authors

Webb1 apr. 2011 · Proteasome inhibitors enhance bone formation and osteoblastic differentiation in vivo and in vitro. In the present study, we examined whether the … WebbLactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC₅₀ = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities … heatherhouse.com

APExBIO - Lactacystin (Synthetic) Proteasome inhibitor CAS

Webbför 2 dagar sedan · Similar to the ACTB intron reporter (Extended Data Fig. 1c), the 6.9-fold loss of eGFP in the Pep30 cell library was reduced to 2.3-fold after 24 h of proteasome inhibition (lactacystin), with ... Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first identified as an inducer of neuritogenesis in neuroblastoma cells in 1991. The target of lactacystin was subsequently found to be the proteasome on the basis of its affinity for certain catalytic subunits of the proteasome by Fenteany and co-workers in 1995. The proteasome is a protein … Webb9 sep. 2016 · proteasome inhibitor (Fenteany et al, 1994) whose main mode of action is the irreversible modification of the proteasome b5 subunit at its highly conserved active site, an amino-terminal threonine residue (Fenteany & Schreiber, 1998). Neither lactacystin nor its active intermediates detectably affect many other commonly tested movie intersect on youtube